I played a lot of Railroad and Transport Tycoon. Some of the recent attempts to recreate the experience fall flat because they either look hideous or they are too busy delivering an ultra-realistic world/train-driving simulation.
On Steam, “Mashinky”  popped onto my queue and it looks like Jan Zeleny may have found a great middle ground.
There is a tycoon-like, low-rez tiled experience which he maps into a more beautifully rendered 3d mode with fancy camera options.
Steam reviews are mixed, but this is now top of my queue to try and Secret World.